Device-Based Treatment for Autonomic Imbalance
Chronically elevated sympathetic nervous system activity is an underlying pathophysiological mechanism of a number of disease conditions.
A promising investigational device treatment option involves neuromodulation of the carotid baroreflex which is essential to the body’s natural regulation of the autonomic nervous system, including the sympathetic and parasympathetic systems.
The baroreflex relies on specialized stretch-sensitive baroreceptors located along the carotid arteries in the neck. Baroreceptors monitor increased arterial wall stretch and send signals to the brain resulting in reduced sympathetic tone and increased parasympathetic activity.